Senescence and senotherapies in biliary atresia and biliary cirrhosis.

Giulia Jannone,Eliano Bonaccorsi Riani,Catherine de Magnée,Roberto Tambucci,Jonathan Evraerts,Joachim Ravau,Pamela Baldin,Caroline Bouzin,Axelle Loriot,Laurent Gatto,Anabelle Decottignies,Mustapha Najimi,Etienne Marc Sokal

Aging（2023）

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摘要

BA livers displayed advanced cellular senescence at diagnosis that continued to progress until liver transplantation. HALPC reduced early senescence and improved liver disease in a preclinical model of BA, providing encouraging preliminary results regarding the use of senotherapies in pediatric biliary cirrhosis.

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关键词

senescence, senotherapy, liver, biliary cirrhosis, biliary atresia

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