Association of MGMT Promotor Methylation With Survival in Low-grade and Anaplastic Gliomas After Alkylating Chemotherapy.

Connor J Kinslow,Ann Mercurio,Prashanth Kumar,Ali I Rae,Markus D Siegelin,Jack Grinband,Kekoa Taparra,Pavan S Upadhyayula,Guy M McKhann,Michael B Sisti,Jeffrey N Bruce,Peter D Canoll,Fabio M Iwamoto,Lisa A Kachnic,James B Yu,Simon K Cheng,Tony J C Wang

JAMA oncology（2023）

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摘要

This study suggests that mMGMT is associated with response to alkylating chemotherapy for low-grade and anaplastic gliomas and may be considered as a stratification factor in future clinical trials of patients with IDH-wild-type and IDH-mutant and codeleted tumors.

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