A tetranuclear polypyridylruthenium(II) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium.

Kartika Wardhani,Aviva Levina,Biyun Sun,Georges E R Grau,F Richard Keene,J Grant Collins,Peter A Lay

Chemical communications (Cambridge, England)（2023）

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摘要

A new photoluminescent polypyridylruthenium(II) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.

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关键词

brain microvascular endothelium,extracellular vesicle penetration

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