LIPUS-SCs-Exo promotes peripheral nerve regeneration in cavernous nerve crush injury-induced ED rats via PI3K/Akt/FoxO signaling pathway.

Kun Ye,Zitaiyu Li,Yinghao Yin,Jun Zhou,Dongjie Li,Yu Gan,Dongyi Peng,Ming Xiao,Liangyu Zhao,Yingbo Dai,Yuxin Tang

CNS neuroscience & therapeutics（2023）

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摘要

Our study revealed that LIPUS stimulation could regulate the gene of MPG neurons by changing miRNAs derived from SCs-Exo, then activating the PI3K-Akt-FoxO signal pathway to enhance nerve regeneration and restore erectile function. This study had important theoretical and practical significance for improving the NED treatment.

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关键词

erectile dysfunction, exosomes, low-intensity pulsed ultrasound, nerve regeneration, Schwann cells

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