Bile exosomal miR-182/183-5p increases cholangiocarcinoma stemness and progression by targeting HPGD and increasing PGE2 generation.

Lizhuang Shu,Xingyong Li,Zengli Liu,Kangshuai Li,Anda Shi,Yongchang Tang,Liming Zhao,Lingling Huang,Zhiyue Zhang,Dong Zhang,Shaohui Huang,Shuo Lian,Guoli Sheng, Zhangdi Yan,Zongli Zhang,Yunfei Xu

Hepatology (Baltimore, Md.)（2023）

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摘要

CCA cells secret exosomal miR-182/183-5p into bile, which targets HPGD in CCA cells and MCs and increases PGE2 and VEGF-A release. PGE2 promotes stemness by activating PTGER1. Our results reveal a type of CCA self-driven progression dependent on bile exosomal miR-182/183-5p and MCs, which is a new interplay pattern of CCA and bile.

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