Heterogeneity of Repolarization and Cell-Cell Variability of Cardiomyocyte Remodeling Within the Myocardial Infarction Border Zone Contribute to Arrhythmia Susceptibility.

Matthew Amoni,Dylan Vermoortele,Samaneh Ekhteraei-Tousi,Rosa Doñate Puertas,Guillaume Gilbert, Mohamad Youness,Bernard Thienpont,Rik Willems,H Llewelyn Roderick,Piet Claus,Karin R Sipido

Circulation. Arrhythmia and electrophysiology（2023）

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摘要

Heterogeneous cardiomyocyte remodeling in the BZ is driven by uniquely altered gene expression, related to heterogeneity in the local microenvironment, and translates to heterogeneous repolarization and arrhythmia vulnerability in vivo.

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关键词

arrhythmias, cardiac remodeling, hypertrophy, magnetic resonance imaging, myocardial infarction, single-cell gene expression analysis, voltage-sensitive dye imaging

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