Prolonged experimental sleep disturbance affects the inflammatory resolution pathways in healthy humans

•Prolonged experimental sleep disturbances in humans downregulate inflammatory resolution mediators, in particular the D-series resolvins.•Most of the D-series resolvins remain downregulated following three nights of recovery sleep, suggesting a longer lasting effect of sleep disturbances on inflammatory resolution processes.•Sleep disturbances may contribute to the many diseases involving immunopathology by disruption of inflammatory resolution processes.