Mitochondrial dysfunction and cardiac ischemia/reperfusion injury are attenuated by nandrolone: Role of JAK-STAT3 pathway

Ainá E. Domingos,Fernando A.C. Seara,Dahienne F. Oliveira,Leonardo Maciel,Raiana A.Q. Barbosa,Luciane C. Barcellos, Verônica S. Pinto,Rodrigo S. Fortunato,Jose H.M. Nascimento

Steroids（2023）

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摘要

•Acute nandrolone treatment decreased the susceptibility to cardiac IR injury;•Cardioprotection elicited by nandrolone is triggered by JAK/STAT3 pathway;•IR-induced mitochondrial damage was attenuated by nandrolone.

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关键词

mitochondrial dysfunction,ischemia/reperfusion ischemia/reperfusion injury,cardiac ischemia/reperfusion,nandrolone,jak-stat

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