Regulation of megakaryo/thrombopoiesis by endosomal toll-like receptor 7 and 8 activation of CD34+ cells in a viral infection model

Camila Sofía Rodríguez,Nancy Charó,Silvio Tatti,Ricardo Martín Gómez,Lina Paola D’Atri,Mirta Schattner

Research and Practice in Thrombosis and Haemostasis（2023）

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摘要

•The role of receptors that sense viruses in megakaryocyte and platelet production is unknown.•Human stem cells were used to study platelet biogenesis in a viral infection model.•Virus recognition by toll-like receptor 7 (TLR7) impairs megakaryocyte and platelet development.•Viral infection and TLR7 activation increase megakaryocytes with immune properties.

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megakaryocytes,platelets,RNA viruses,toll-like receptor 7,toll-like receptor 8

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