ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation

Shayin V. Gibson, Elizabeta Madzharova, Amandine C. Tan,Michael D. Allen,Ulrich auf dem Keller,J. Louise Jones,Edward P. Carter,Richard P. Grose

Matrix Biology（2023）

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摘要

•Metzincins display both pro- and anti-invasive effects in breast cancer.•Loss of myoepithelial ADAMTS3 expression drives invasion.•Degradomic analysis implicates fibronectin as a novel ADAMTS3 substrate.•ADAMTS3 restricts cell invasion through fibronectin degradation and reduced integrin α5β1 signalling.

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关键词

fibronectin degradation,cancer invasion,early breast cancer progression,breast cancer

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