In utero exposure to diethylstilbestrol and blood DNA methylation in adult women: Results from a meta-analysis of two cohort studies

Clara Bodelon,Gretchen L. Gierach,Elizabeth E. Hatch,Emily Riseberg,Amy Hutchinson,Meredith Yeager,Dale P. Sandler,Jack A. Taylor,Robert N. Hoover,Zongli Xu,Linda Titus,Julie R. Palmer,Rebecca Troisi

Environmental Research（2023）

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摘要

•In utero exposure to diethylstilbestrol (DES) has been linked to adverse reproductive outcomes.•Animal studies have shown associations between prenatal DES exposure leads to altered DNA methylation.•DNA methylation at ten sites was associated with prenatal DES exposure.•These ten sites were located in genes related to cell proliferation and differentiation.

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关键词

blood dna methylation,utero exposure,diethylstilbestrol,meta-analysis

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