Local sustained release of PD-1 monoclonal antibody and lenvatinib by thermo-sensitive hydrogel for improving tumor immunotherapy

Lin Zhai,Yujie Shi,Yi Yan,An Lu,Xiaoyu Liu,Lei Lei,Yi Sun,Linxia Jiang,Xiangyu Wang,Honggang Qian,Jiancheng Wang

Chinese Chemical Letters（2023）

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摘要

This study fabricates a temperature-sensitive in-situ gel based on PLGA-PEG-PLGA copolymers for local administration of anti-PD1 and lenvatinib mesylate (P&L@Gel). P&L@Gel achieves better tumor-inhibiting effects and leads to 2.2-fold increase of level CD8+ T cells and the polarization of TAM from M2 to M1.Image, graphical abstract

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关键词

Lenvatinib, PD-1 antibody, Thermosensitive hydrogels, Topical administration, Tumor immunotherapy

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