414. Individuals With Substance Use Disorders Exhibit Heightened Anxiety and Anterior Cingulate Activation During Fear Conditioning

Fear conditioning (FC), or learning from aversive experience, is an important process influencing action-outcome associations. Frontocingulate, insular, and amygdalar regions are: (1) associated with FC; and (2) altered in substance use disorders (SUD). However, it is unclear whether FC processes are specifically disrupted in SUD. This investigation examined the hypothesis that SUD individuals show altered neural processing during FC.