Hypoxic tumor-derived exosomal miR-21 induces cancer-associated fibroblast activation to promote head and neck squamous cell carcinoma metastasis

Beibei Ye,Yuansheng Duan,Mengqian Zhou,Yuxuan Wang,Qingchuan Lai,Kai Yue,Jiayan Cao,Yansheng Wu,Xudong Wang,Chao Jing

Cellular Signalling（2023）

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摘要

•Head and neck squamous cell carcinoma have poor prognosis due to metastasis.•microRNA-21-5p, hypoxia, and cancer associated fibroblasts may lead to metastasis.•Hypoxia promotes microRNA-21-5p levels in exosomes that transform fibroblasts.•microRNA-21-5p increases invasion and metastasis both in vivo and in vitro.•microRNA-21-5p targets YOD1 in cancer associated fibroblasts to promote metastasis.

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关键词

Head and neck squamous cell carcinoma, HIF1 & alpha,, MiR-21, Exosome, Cancer-associated fibroblasts

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