13. Metabolomic Signatures Associated With Weight Gain and Psychosis Spectrum Diagnoses

Psychosis spectrum disorders are characterized by intrinsic metabolic dysfunction. Beyond the intrinsic metabolic risk, antipsychotics, the cornerstone of treatment for psychosis, incur additional metabolic adversities including weight gain. Currently, major gaps exist in understanding psychosis illness biomarkers, as well as risk factors and mechanisms for antipsychotic-induced weight gain. Metabolomic profiles may provide insight into candidate biomarkers of psychosis disorders and antipsychotic-induced weight gain.