Amplified gut feelings under inflammation and depressed mood: A randomized fMRI trial on interoceptive pain in healthy volunteers

Sven Benson,Franziska Labrenz, Simone Kotulla, Lisa Brotte, Philipp Rödder, Bastian Tebbe,Nina Theysohn,Harald Engler,Sigrid Elsenbruch

Brain, Behavior, and Immunity（2023）

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摘要

•Inflammation and depressed mood interact as vulnerability factors for pain.•States of inflammation and acute sadness impacted on pain unpleasantness.•Interaction effects observed for anticipatory activation of caudate and hippocampus.•This may reflect a nocebo mechanism relevant to hypervigilance and hyperalgesia.

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关键词

interoceptive pain,gut feelings,depressed mood,fmri trial,inflammation

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