Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression

Jennifer Vande Voort,Balwinder Singh,Patricio Riva-Posse,Sophie Erhardt,Lilly Schwieler,Vanessa Pazdernik,Mark Frye,Susannah Tye

Biological Psychiatry（2023）

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摘要

Ketamine reduces depression, anhedonia and suicidality, in part, by mediating inflammation. We aimed to determine the relationship between ketamine’s immunomodulatory action and its antianhedonic/antisuicidal efficacy.

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treatment resistant depression,ketamine,kynurenine levels,suicidal ideation

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