Satellite Imaging of Global Urbanicity relates to Brain and Behavior in Young People

Abstract Urbanicity is a growing environmental challenge for mental-health. While the impact of urban life on brain and behavior might be distinct in different sociocultural conditions and geographies, there might exist features shared between regions. To investigate correlations of urbanicity with brain structure and function, neuropsychology and mental illness symptoms in young people from China and Europe, we developed a remote-sensing satellite-measure termed ‘UrbanSat’ quantifying population-density, a general measure of urbanicity. UrbanSat is correlated with brain volume, surface area and brain-network-connectivity in the medial prefrontal cortex and cerebellum, which mediate its effect on perspective-taking and depression- symptoms. Susceptibility to high population-density is greatest during childhood for the cerebellum and from childhood to adolescence for the prefrontal cortex. As UrbanSat can be generalized to different geographies, it will enable assessing the impact of urbanicity on mental illness and resilience globally, especially in young people where prevention and early interventions are most effective.