Integrative Network Analysis of Early-Stage Lung Adenocarcinoma Identifies Aurora Kinase Inhibition as Interceptor of Invasion and Progression
crossref(2021)
摘要
Abstract We present a gene signature distinguishing invasive and indolent tumors among early-stage lung adenocarcinoma (esLUAD). An Invasiveness Score estimated using the gene signature was strongly associated with survival of esLUAD patients in multiple independent cohorts and with the invasiveness phenotype in lung cancer cell lines. Regulatory network analysis identified aurora kinase as one of master regulators of the gene signature and perturbation of aurora kinases in vitro and in vivo reduced tumor invasion. Our study suggests aurora kinases as a novel target for treating early-stage invasive lung adenocarcinoma.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要