Tumor Abnormal Protein Detection is An Effective Screening Method for Solid Malignancies

Abstract Background: Detection of tumor abnormal protein (TAP) is a recently developed but not widely used method for screening malignancies. This study is aimed to assess the ability of TAP level in distinguishing solid malignancies. Methods: The TAP levels were compared between malignancies and benign disease patients, and the distinguish ability were evaluated by receiver operating characteristic (ROC) curve analysis. We further analyzed TAP levels in physical examination populations with different genders and age， and compared clinical parameters in TAP positive and negative groups. Results: We found that TAP levels were getting higher from benign to precancerous lesions and to malignancies, and TAP levels were decreased after tumor resection. ROC curve analysis showed that TAP levels might aid to distinguish between malignancies and benign diseases. In the physical examination populations, the positive ratio of TAP was 3.7% (4.6% to female and 3.1% to male), and the TAP levels were higher in female. The TAP levels in populations above 60 year age were higher than those in less than 60 years, which increased with age. The hemoglobin levels were lower in TAP positive populations. Conclusion: TAP was an effective biomarker of screening and following-up for malignancies. There may be some potential links between TAP and hemoglobin, which deserve further studies.