BDNF rs6265 Met carriers with alcohol use disorder show greater age-related decline of N-acetylaspartate in left dorsolateral prefrontal cortex

Timothy C. Durazzo,M. Windy McNerney,Annika M. Hansen,Meng Gu,Matthew D. Sacchet,Claudia B. Padula

Drug and Alcohol Dependence（2023）

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摘要

•BDNF rs6265 genotyping was completed in those with alcohol use disorder.•Brain metabolites were acquired in the left dorsolateral prefrontal cortex (DLPFC).•rs6265 Met carriers had greater age-related decline in NAA/Cr than Val homozygotes.•Greater age-related decline of NAA/Cr in Met carriers may impact rTMS efficacy..

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关键词

Brain derived neurotrophic factor, Alcohol use disorder, N-acetylaspartate, Magnetic resonance spectroscopy

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