Plasma neurofilament light chain level is not a biomarker of Charcot-Marie-Tooth disease progression: results of 3-year follow-up study.

Signe Setlere,Arta Grosmane,Natalja Kurjane,Linda Gailite,Dmitrijs Rots,Kaj Blennow,Henrik Zetterberg,Viktorija Kenina

European journal of neurology（2023）

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摘要

Our study verifies increased plasma NfL concentrations in patients with CMT compared with controls. Longitudinal 3-year data showed a variable change in NfL levels between CMT subtypes. There was no association between change in NfL over time and disease severity. These findings suggests that NfL is not a biomarker for CMT progression.

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genetic and inherited disorders,polyneuropathy

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