Chemistry of polyhalogenated nitrobutadienes, 19: Synthesis of new types of compound modulating the biological activity of Type I Interferons (IFN-I)

Viktor A. Zapol'skii,Milagros Burgi,Marcos Oggero,Mariela Bollati-Fogolin,Dieter E. Kaufmann

ARKIVOC（2023）

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摘要

The synthesis of ten new types of compound derived from polyhalonitroalkenes is described starting from the versatile solvent trichloroethene. The new compounds modulate the biological activity of Type I Interferons (IFN-I). Three of them (bornylamine derivative P6C11, chlorothiophene P28G6, and nitroindole P28F7) are promising candidates to inhibit rhIFN activity.

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关键词

Nucleophilic vinylic substitution, 2-nitropentachlorobutadiene, heterocyclizations, indoles, pyrazoles, thiophenes, Interferons

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