Surgical techniques and oncologic outcomes of pure transperitoneal laparoscopic radical nephroureterectomy for upper urinary tract urothelial carcinoma

Abstract Introduction: To discuss the clinical feasibility and oncologic outcomes of pure transperitoneal laparoscopic radical nephroureterectomy (LSRNU) for upper urinary tract urothelial carcinoma (UTUC).Methods: Between July 2010 and December 2020, 115 patients were admitted to the hospital with a diagnosis of UTUC treated with pure LSRNU by one surgeon. A special laparoscopic bulldog clamp was placed at the bladder cuff before cutting and suturing. The clinical and follow-up data were preoperatively collected and analyzed. Overall survival (OS) and cancer-specific survival (CSS) were estimated by the Kaplan–Meier method.Results All surgeries were completed uneventfully. The mean operative time was 145.69 minutes. The mean estimated blood loss was 56.61 ml. The mean removal time of the drain was 3.46 days. The mean time to liquid diet was 1.32 days, and the ambulation time was 1.50 days. All surgeries were effectively completed, and no case required open conversion. According to the Clavien–Dindo classification system, postoperative complications occurred in two patients (II, III). The mean length of postoperative hospital stay was 5.78 days. The median follow-up duration was 54.50 months. Recurrence in the bladder was 16.0% (15/94), compared with 4.6% (4/87) in the contralateral upper tract. The 5-year OS and CSS rates were 78.9% and 81.4%, respectively.Conclusion Pure transperitoneal laparoscopic RNU is a safe and effective minimally invasive technology for the management of UTUC.