Serum albumin and the short-term mortality in individuals with chronic systolic heart failure in intensive care unit: an analysis of MIMIC

Abstract Decreased albumin levels are common in chronic heart failure (HF), but little is known about its role in mortality risk in HF. This study developed a cohort prediction model based on 7,121 individuals with heart failure to evaluate the short-term mortality and prognostic role of albumin in patients with chronic HF. The cohort was from intensive care unit between 2001 to 2012 in a publicly available clinical database in intensive care called MIMIC III. We used a generalized additive model to determine the nonlinear correlation between serum uric acid and 14th - day, 28th - day and 90th day all-cause mortality in patients with heart failure. The results showed that serum albumin was an independent risk factor for 14th -,28th - and 90th day all-cause mortality, and had a linear relationship with all-cause mortality in Chronic systolic heart failure. There is an interaction between ARDS and the influence of albumin on the outcome. The all-cause mortality on the 90th day predicted better clinical results with the all-cause mortality on the 14th day.