Anticancer Activity of Nano Uncaria gambir

Abstract Cancer is a disease caused by uncontrolled cell growth. Cancer treatments, such as chemotherapy, have tended to cause adverse effects for patients. An alternative that can be described is the development of natural-based cancer therapies that have relatively low side effects. The development of Na-alginate as a matrix for nanoencapsulation of Uncaria gambir has shown growth inhibition activity against HeLa and T47D cell lines. The EC50 ± SE of U. gambir extract on the HeLa cell line was 1055.14 ± 42.52 µg/mL while on the T47D cell line 297.15 ± 15.41 µg/mL. On the other hand, the Ug-NPs anticancer activity was substantially higher with EC50 ± SE for HeLa cell line 28.12 ± 27.10 µg/mL, and T47D cell line 10.39 ± 3.50 µg/mL. Therefore, the nanoencapsulation of U. gambir extracts has increased solubility, selectivity, and activity.