Sleep Health Characteristics And Risk Of Kidney Stones: A Cross- Sectional Study

Abstract Objective:To evaluate the association between sleep health characteristics and kidney stones.Methods:We performed a cross-sectional analysis using data from National Health and Nutrition Examination Survey (NHANES 2007-2008). The primary exposures were self-reported sleep duration, obstructive sleep apnea and sleep difficulty. The primary outcome was nephrolithiasis. We examined the association between sleep health characteristics and kidney stones using multivariable logistic regression models and reported odds ratios (ORs).Results:After fully multivariate adjustment, obstructive sleep apnea is positively associated with the risk of kidney stones (OR=1.34, 95% CI:1.10–1.63, P=0.0037). Then, the sleep difficulty group had a 1.49-fold increased risk of kidney stone (95% CI:1.23–1.80, P < 0.0001). However, insufficient (< 7 Hours/Night) sleep seems not to be associated with kidney stone (OR=1.08, 95%CI: 0.90-1.29, P=0.3992).Conclusions:After controlling for known risk factors, obstructive sleep apnea and sleep difficulty were associated with an increased likelihood of kidney stone incidence.