Depleting Cationic Lipids Involved in Antimicrobial Resistance Drives Adaptive Lipid Remodeling in Enterococcus faecalis

Rafi Rashid, Zeus Jaren Nair, Dominic Ming Hao Chia,Kelvin Kian Long Chong,Amaury Cazenave Gassiot,Stewart A. Morley,Doug K. Allen,Swaine L. Chen,Shu Sin Chng,Markus R. Wenk,Kimberly A. Kline

mBio（2023）

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摘要

The cell membrane plays a pivotal role in protecting bacteria against external threats, such as antibiotics. Cationic phospholipids such as lysyl-phosphatidyglycerol (L-PG) resist the action of cationic antimicrobial peptides through electrostatic repulsion.

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