A Single Dose Of Fel d 1 Monoclonal Antibodies Regulates Molecular Signatures of Asthma In Nasal Mucosa Upon Cat Allergen Challenge In A Phase 2 Study

Meagan OBrien,Kaitlyn Gayvert,Matthew Wipperman, Fredreic de Blay,Alina GHERASIM,Nathalie Domis,Pretty Meier,Michelle DeVeaux,Lorah Perlee,Gary Herman,Wei Keat Lim,Jennifer Hamilton,Sara Hamon

Journal of Allergy and Clinical Immunology（2023）

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摘要

Allergies to cats are a major risk factor in the development of asthma. We aimed to investigate the effect of a single dose of Felis domesticus allergen 1 (Fel d 1) monoclonal antibodies (REGN1908/1909) on asthma signatures in a clinical trial assessing efficacy of the antibodies for prevention of early asthma responses (EAR) by cat allergen in cat-allergic mild asthmatic subjects (NCT03838731).

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asthma,cat allergen challenge,nasal mucosa,monoclonal antibodies

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