Peripheral nervous system manifestations associated with COVID-19

A novel severe acute respiratory syndrome coronavirus 2 has been identified. The disease caused by this virus was termed Coronavirus disease 2019 (COVID-19). The most common reported symptoms include fever, cough, headache, and fatigue. Vast central nervous system and peripheral nervous system complications associated with SARS-CoV-2 have been recently reported. The main mechanism of SARS-CoV-2 and neuroinvasion is hypothesized to be related to angiotensin converting enzyme-2 receptor. Damage to nervous system is mainly by hyperactivation of the immune system with overproduction of inflammatory mediators and producing autoantibodies. Here we review the peripheral nervous system manifestations and complications associated with COVID-19 and highlight its immune-mediated mechanism of pathology. Common neurological complications in COVID-19 include Guillain–Barré syndrome, myasthenia gravis, Cranial neuropathy, and myopathy. Our aim is to update the physicians working with suspected cases of COVID-19 about the possible neurological complication.