Organocatalytic Dynamic Kinetic Asymmetric Transformations

A. Cordova, K. Zhang, L. Deiana

Science of Synthesis(2023)

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摘要
Dynamic kinetic asymmetric transformations (DYKAT) are an important way of converting simple organic molecules into complex small molecules as single diastereo- and enantiomers. Herein we describe selected examples that are catalyzed by small organic molecules, which utilize activation mechanisms similar to enzymes for accomplishing the high stereoselectivity. The research area of DYKAT is growing and remarkable examples for producing important organic molecules and pharmaceuticals are demonstrated. In this context, organocatalysis will play an important role. [GRAPHICS] .
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关键词
dynamic kinetic asymmetric transformation,organocatalysis,highly enantioselective,highly diastereoselective,dual catalysis,hydrogen-bond donation,smallmolecule catalysis
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