P-98 Environmental contamination with and internal occupational exposure to antineoplastic agents and evaluation of genotoxic and epigenetic effects thereof
Abstracts(2023)
摘要
Introduction
It is important to monitor unintended exposure to antineoplastic drugs (ANDs) and potential effects occurring after exposure. Our aims were to develop a method sensitive enough to measure trace levels of ANDs in urine, evaluate environmental contamination and occupational exposure to ANDs. Finally, we aimed to study the link between exposure and genotoxic/epigenetic effects.Materials and Methods
UPLC-UniSpray-MS/MS was used for quantification of ANDs in urine (n=83), while UPLC-ESI-MS/MS was used for analysis of wipe samples (n=62) collected in 6 different departments from a university hospital. Novum simplified liquid cartridges were used for extraction of urine samples, liquid extraction was used for wipe samples. The link between exposure and effects was studied through a systematic review.Results and Conclusions
A method for urine analysis was fully developed and validated with LLOQs of 0.05 ng/mL, 0.3 ng/mL and 0.7 ng/mL for cyclophosphamide, ifosfamide and paclitaxel, respectively. All wipe samples and 17 urine samples had quantifiable concentrations of at least one compound. Concentrations in urine ranged fromEthical approval
‘Conseil d’Ethique et de Déontologie de l’Université de Tlemcen’ (15/12/2016).Funding
Industrieel Onderzoeksfonds KU Leuven Program: C3 project: (C32/15/029) Occupational dermal exposure to cytostatics (3M170331). The Research Foundation – Flanders (1SD2322N). The authors declare no conflict of interest.查看译文
关键词
internal occupational exposure,genotoxic,antineoplastic agents,epigenetic effects
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