Systemic immune parameters after prior radiation therapy in patients receiving immune checkpoint inhibitors.

Vatsala Mundra,Yuqiu Yang,Mitchell S von Itzstein,Farjana Fattah,Amrit S Gonugunta,Raquibul Hannan,Laurentiu M Pop, Yuanyuan Zhang,Yiqing Wang,Thomas Sheffield,Yang Xie,Jonathan E Dowell,Jade Homsi,Sawsan Rashdan,Jason Park,Quan-Zhen Li,Edward K Wakeland,David E Gerber

Translational Oncology（2023）

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摘要

Prior RT is associated with few changes in systemic immune parameters in patients receiving ICI. The underlying mechanisms and optimal approach to harnessing the potential synergy of RT and ICI require further prospective clinical investigation.

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关键词

Abscopal effect,Autoantibodies,Cytokines,Immunotherapy,Radiation

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