PBRM1 loss redirects chromatin remodelling complex to recruit oncogenic factors
NATURE CELL BIOLOGY（2023）
摘要
The loss of the polybromo-1 (PBRM1) subunit in a class of SWI/SNF chromatin remodelling complexes in clear cell renal cell carcinoma redirects the deficient complexes to aberrant enhancer regions. The catalytic subunit SMARCA4 of the PBRM1-deficient complexes recruits the nuclear factor-kappa B transcription factor to drive pro-tumorigenic programs.
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