Lba03-04 mri-derived tumor volume as a predictor of biochemical recurrence and adverse pathology in patients after radical prostatectomy: a propensity score matching study

You have accessJournal of UrologyCME1 Apr 2023LBA03-04 MRI-DERIVED TUMOR VOLUME AS A PREDICTOR OF BIOCHEMICAL RECURRENCE AND ADVERSE PATHOLOGY IN PATIENTS AFTER RADICAL PROSTATECTOMY: A PROPENSITY SCORE MATCHING STUDY Xuehua Zhu, Zenan Liu, Jide He, Ziang Li, Wei He, and Jian Lu Xuehua ZhuXuehua Zhu More articles by this author , Zenan LiuZenan Liu More articles by this author , Jide HeJide He More articles by this author , Ziang LiZiang Li More articles by this author , Wei HeWei He More articles by this author , and Jian LuJian Lu More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003426.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To investigate the predictive value of MRI-derived tumor volume (TV) of biochemical recurrence (BCR) and adverse pathology (AP) in patients following radical prostatectomy (RP). METHODS: The data of 565 patients with prostate cancer (PCa) receiving RP in a single institution between 2010 to 2021 were retrospectively analyzed. All suspicious tumor foci were delineated manually using ITK-SNAP software as the region of interest (ROI). The sum of the TV of all lesions was calculated automatically based on the voxel in the ROIs to acquire the final TV parameter. TV was categorized as low-volume (≤6.5 cm3) and high-volume (>6.5 cm3) based on the cut-off value. Univariate and multivariate Cox and logistic regression analyses were performed to identify independent predictors of BCR and AP. The Kaplan-Meier method with the log-rank test was conducted to compare the BCR-free survival (BFS) between the low and high-volume groups. RESULTS: Results: All the included patients were divided into the low-volume group (n=337) and the high-volume group (n=228). The TV was an independent predictor of BFS in the multivariate Cox regression analysis (Hazard Ratio (HR) [95% CI]: 1.550 [1.066-2.256], p=0.022 ). The Kaplan-Meier analysis demonstrated that low volume was associated with a better BFS than high-volume before PSM (p=0.00). One hundred and fifty-eight pairs were obtained by 1:1 PSM to balance the baseline parameters between the two groups. After the PSM, low-volume remained to be associated with a better BFS than high-volume (p=0.006). In addition, patients with AP had a larger median TV than patients without AP (6.10 ml vs. 2.67 ml, p=0.00). TV as a categorial variable was an independent factor of AP in multivariate logistic regression analysis (Odd ratio (OR) [95% CI]: 1.821 [1.064-3.115], p=0.029). After balancing the potential factors influencing AP by 1:1 PSM, 162 new pairs were identified. The high-volume group had a higher AP rate than the low-volume group after PSM (75.9% vs. 64.8%, p=0.029). CONCLUSIONS: Conclusions: We adopted a novel approach to acquiring the TV parameter on preoperative MRI. A threshold value(6.5cm3) of the TV was identified from the ROIs on the MRI. TV was significantly associated with BFS and AP of patients undergoing RP, which was further illustrated by PSM analysis. MRI-derived TV may serve as a predictive marker for assessing BFS and AP in further studies, which will facilitate clinical decision-making and patient counseling. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1193 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Xuehua Zhu More articles by this author Zenan Liu More articles by this author Jide He More articles by this author Ziang Li More articles by this author Wei He More articles by this author Jian Lu More articles by this author Expand All Advertisement PDF downloadLoading ...