Supplementary Figures from Determination of Tumor Margins with Surgical Specimen Mapping Using Near-Infrared Fluorescence

1. Supplementary Figure 1: Patient and tumor characteristics. 2. Supplementary Figure 2: Flow diagram of tumor-mapping analysis. The primary tumor specimen (A) is imaged using a closed-field fluorescence imaging device (B) and sectioned into breadloafs (C). H&E slides with areas of tumor tissue marked by a board-certified pathologist are analyzed, and tumor tissue distance to the deep margin surface is measured. Tumor depth in areas with fluorescence are compared to tumor depth in areas without fluorescence. 3. Supplementary Table 1: Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of fluorescence signal for areas of the primary tumor specimen with tumor tissue {less than or equal to} 1 mm from the deep margin surface given by cohort. 4. Supplementary Table 2: Sensitivity, specificity, PPV, and NPV of fluorescence signal for areas of the primary tumor specimen with tumor tissue {less than or equal to} 2 mm from the deep margin surface given by cohort.