Supplementary Figure 2 from Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

PDF file - 1.7MB, Figure S2: Changes in Imaging Parameters over Time. Based on the three patients groups from the microvessel tumor flow analysis, the plots show: (A) contrast-enhanced T1-weighted tumor volumes, (B) FLAIR tumor volumes and (C) permeability (Ktrans) of the tumor over time. Patients with an increase and decrease in flow showed the same changes in contrast-enhanced tumor volume and peritumoral vasogenic edema during treatment. Indeed, redefining PFS using the Response Assessment in Neuro-Oncology (RANO) Working Group criteria instead of Macdonald did not change the outcome of any test in our study. Numerical data show log-scaled averaged values (�SEM) and values at day -1 were set as 100% in all lesions. P-values show results of Mann-Whitney tests for the difference between patients with stable flow and increased or decreased flow (Holm-Bonferroni corrected).