Comparison of circulating tumor DNA between African American and Caucasian patients with metastatic castrate-resistant prostate cancer post-abiraterone and/or enzalutamide.

Albert Jang,Sree M Lanka,Minqi Huang,Crystal V Casado,Sydney A Caputo,Patrick L Sweeney,Kanika Gupta,Olivia Pocha,Nicholas Habibian,Madeline E Hawkins,Alexandra D Lieberman,Jennifer Schwartz,Ellen B Jaeger,Patrick J Miller,Jodi L Layton,Pedro C Barata,Brian E Lewis,Elisa M Ledet,Oliver Sartor

The Prostate（2023）

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摘要

Compared to Caucasian men, African American men with mCRPC after exposure to abiraterone and/or enzalutamide had a higher incidence of somatic CDK12 P/LP mutations and KIT amplifications and P/LP mutations based on ctDNA. African American men also had more frameshift mutations. We hypothesize that these findings have potential implications for tumor immunogenicity.

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关键词

abiraterone,castration-resistant,circulating tumor DNA,enzalutamide,somatic mutation

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