Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles.

Alex G Hamilton,Kelsey L Swingle,Michael J Mitchell

PLoS biology（2023）

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摘要

The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic.

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关键词

lipid nanoparticles,nucleic acid delivery,biotechnology

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