mTOR/α-ketoglutarate-mediated signaling pathways in the context of brain neurodegeneration and neuroprotection

Olha Kostiuchenko,Iryna Lushnikova,Magdalena Kowalczyk,Galyna Skibo

BBA advances（2022）

引用 3|浏览4

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摘要

•mTOR and AKG are involved in the regulation of energy homeostasis.•An imbalance of mTOR signaling is correlated with neurological disorders.•AKG metabolism could overlap with mTOR signaling via ATP synthase inhibition.•AKG may activate mTOR by replenishing the TCA-intermediate pool.•Modulation of mTOR activity with AKG may increase the effectiveness of therapeutic strategies in brain disorders treatment.

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关键词

mTOR,α-ketoglutarate (AKG),Metabolism,Autophagy,Aging,Neurodegeneration,Neuroprotection

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