Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program.

Jovanka Gencel-Augusto,Xiaoping Su,Yuan Qi,Elizabeth M Whitley,Vinod Pant,Shunbin Xiong,Vrutant Shah,Jerome Lin, Encarnacion Perez,Marta L Fiorotto,Iqbal Mahmud,Abhinav K Jain,Philip L Lorenzi,Nicholas E Navin, Ellen R Richie,Guillermina Lozano

Cancer discovery（2023）

引用 4|浏览15

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摘要

New mouse models with TP53R342P (monomer) or TP53A347D (dimer) mutations mimic Li-Fraumeni syndrome. Although p53 monomers lack function, p53 dimers conferred noncanonical tumor-suppressive activities. We describe novel activities for p53 dimers facilitated by PPARs and propose these are "basal" p53 activities.

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关键词

metabolic,tumor-suppressive

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