Combined oral contraceptives may activate the contact system in healthy women.

Jesper Strandberg,Inger Lise Gade,Yaseelan Palarasah,Jørgen Brodersen Gram,Søren Risom Kristensen,Johannes Jakobsen Sidelmann

Research and practice in thrombosis and haemostasis（2023）

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摘要

This study demonstrates an increased CAS capacity in women using COC compared with nonusers and also an increased activity . The results indicate that increased contact activation may contribute to the increased thrombotic risk caused by COC.

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关键词

combined oral contraceptives,complement C1 inhibitor protein,contact system,endogenous kallikrein potential,factor XII

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