Upregulation of the ZNF148/PTX3 axis promotes malignant transformation of dendritic cells in glioma stem-like cells microenvironment.

Shan Cheng,Liang Liu,Delin Wang,Yongdong Li,Suwen Li,Jiaqi Yuan,Shilu Huang,Zhipeng Xu,Bin Jia,Zhe Li,Jun Dong

CNS neuroscience & therapeutics（2023）

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摘要

The ZNF148/PTX3 axis played an important role in regulating the malignant transformation of DCs after cross-talk with GSCs, and this axis may serve as a new target for sensitizing GBM to DC-based immunotherapy.

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关键词

GBM microenvironment,dendritic cells,glioma stem cells,malignant transformation,transcription factor ZNF148

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