Isolation and characterization of novel hydroxyflavone from Kigelia africana (Lam.) Benth. fruit ethyl acetate fraction against CHO 1 and HeLa cancer cell lines: In vitro and in silico studies

Akingbolabo Daniel Ogunlakin,Mubo Adeola Sonibare,Oloruntoba Emmanuel Yeye,Gideon Ampoma Gyebi,Damilare IyinKristi Ayokunle,Olayemi Elizabeth Arigbede,Ibrahim M. Ibrahim,Adeshina Isaiah Odugbemi,Almas Jabeen,Syeda Farah Shah,Farzana Shaheen,Oluwafemi Adeleke Ojo

Journal of Molecular Structure（2023）

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摘要

This study presented the first•Scientific data on the anti-proliferative activity of a novel hydroxyflavone isolated for the first time from Kigelia africana fruit, against cervical cancer (HeLa) and tumorigenic (CHO-1) cells.•Understanding the molecular interaction of the compound against p53 protein target.

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关键词

Kigelia africana,Phytochemistry,Flavonoid,Anti-proliferation,Molecular docking,Molecular dynamic simulation

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