MR elastography identifies regions of extracellular matrix reorganization associated with shorter survival in glioblastoma patients.

Siri Fløgstad Svensson,Skarphéðinn Halldórsson,Anna Latysheva,Elies Fuster-Garcia,Trine Hjørnevik,Jorunn Fraser-Green, Robin Anthony Birkeland Bugge,Jack Grinband,Sverre Holm,Ralph Sinkus,Einar Osland Vik-Mo,Kyrre Eeg Emblem

medRxiv (Cold Spring Harbor Laboratory)（2023）

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摘要

MRE imaging of glioblastoma can provide noninvasive information on intratumoral heterogeneity. Regions of increased stiffness were associated with extracellular matrix reorganization. An expression signal associated with "stiff" biopsies correlated with shorter survival of glioblastoma patients.

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关键词

biomechanics,elastography,extracellular matrix,glioblastoma,stiffness

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