Positron emission tomography with [ 18 F]-DPA-714 unveils a smoldering component in most multiple sclerosis lesions which drives disease progression.

Mariem Hamzaoui,Jeanne Garcia,Giacomo Boffa,Andrea Lazzarotto,Martina Absinta,Vito A G Ricigliano,Theodore Soulier,Matteo Tonietto,Philippe Gervais, Anne Bissery,Céline Louapre,Michel Bottlaender,Benedetta Bodini,Bruno Stankoff

Annals of neurology（2023）

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摘要

[ F]-DPA-714-PET revealed that an unexpectedly high proportion of MS lesions have a smoldering component, which predicts atrophy and clinical progression. This suggests that following the acute phase, most lesions develop a chronic inflammatory component, promoting neurodegeneration and clinical progression. This article is protected by copyright. All rights reserved.

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