Adcy9 gene inactivation improves cardiac function after myocardial infarction in mice

Marine Ferron,Nolwenn Merlet,Teodora Mihalache-Avram,Mélanie Mecteau,Geneviève Brand,Marc-Antoine Gillis,Yanfen Shi, Anna Nozza,Mariève Cossette,Marie-Claude Guertin,Eric Rhéaume,Jean-Claude Tardif

Canadian Journal of Cardiology（2023）

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摘要

Adcy9 inactivation reduced infarct size, pathological remodeling and cardiac dysfunction. These changes were accompanied by preserved myocardial capillary density and increased adaptive immune response. Most of the benefits of Adcy9 inactivation were only observed in the absence of CETP.

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myocardial infarction,cardiac function

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