Synthesis of C3-Halo Substituted Bicyclo[1.1.1]pentylamines via Halosulfoamidation of [1.1.1]Propellane with Sodium Hypohalites and Sulfonamides

Herein, we report a catalyst-free synthesis of C3-halo substituted bicyclo[1.1.1]pentylamines under mild conditions. The reaction involves the use of sodium hypohalites and sulfonamides to generate N-halosulfonamides in situ, which subsequently...