Inhibition of TANK-binding kinase1 attenuates the astrocyte-mediated neuroinflammatory response through YAP signaling after spinal cord injury.

Wenbin Zhang,Mengxian Jia,Jiashu Lian,Sheng Lu,Jian Zhou,Ziwei Fan,Zhoule Zhu,Yaozhi He,Changgang Huang,Mingyu Zhu,Jian Wang,Ying Wang,Zhihui Huang,Honglin Teng

CNS neuroscience & therapeutics（2023）

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摘要

TBK1-medicated innate immune pathway in astrocytes through YAP signaling plays an important role in the pathogenesis of SCI and inhibition of TBK1 may be a potential therapeutic drug for SCI.

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关键词

TBK1,YAP,amlexanox,astrocytes,noncanonical NF-κB signaling pathway,spinal cord injury

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