91. Testing the Ecophenotype Hypothesis: Investigating the Impact of Childhood Maltreatment on White Matter Microstructure in Young People With Conduct Disorder

Sophie Townend,Marlene Staginnus,Jack Rogers,Areti Smaragdi,Anne Martinelli,Nora Raschle,Gregor Kohls,Kerstin Konrad,Christina Stadler,Christine Freitag,Esther Walton,Stephane De Brito,Graeme Fairchild

Biological Psychiatry（2023）

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摘要

Childhood maltreatment is a key risk factor for conduct disorder (CD), and there are suggestions that maltreated and non-maltreated youth with CD may be neurobiologically distinct. Referred to as the ‘ecophenotype hypothesis’, this may explain inconsistent findings in previous studies of structural connectivity in CD youth.

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关键词

Conduct Disorder, childhood maltreatment, Diffusion Tensor Imaging (DTI), Sex differences, white matter

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